milk thistle depression

Milk thistle (Silybum marianum) is a flowering plant belonging to the Asteraceae (daisy) family. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. Studies on cancer cell lines (done in the laboratory) have found that elements in milk thistle: Researchers also are looking at how milk thistle might complement traditional care and treatment in people diagnosed with gastrointestinal cancers. In one clinical trial, 60 people with benign polyps in the colon (which often develop into colon cancer) took a herbal blend with milk thistle, a flaxseed antioxidant, and oat fiber for 2 . Liver Detoxification and Health. and depression. There is a reason why milk thistle is called the "liver herb." The flavonoid combo of silymarin (and especially the phytonutrient silybin) can help rebuild liver cells while it removes toxins from that organ at the same time. Would you like email updates of new search results? 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. This content does not have an Arabic version. There is also concern that milk thistle might affect estrogen levels. Phytother Res. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. Healthline Media does not provide medical advice, diagnosis, or treatment. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Effects of Silybum marianum (L.) Gaertn. J Tradit Complement Med. sharing sensitive information, make sure youre on a federal The study researchers hypothesize that milk thistle's antioxidant qualities make it a good candidate for treating conditions like cancer, hepatitis, NAFLD, diabetes, depression, and heart disease. While more research into milk thistle, silymarin, and its effectiveness in treating OCD is definitely needed, there is a wealth of information supporting the other health benefits of milk thistle for a host of ailments: Liver Health It is believed that milk thistle and silymarin bolsters liver function by prohibiting toxic substances from binding to liver cells (6). Epub 2013 Oct 14. There is no standardized dosage or recommended intake for milk thistle tea, but it's generally considered safe if consumed in moderation. IBM Micromedex. 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects - STYLECRAZE Rev Diabet Stud. Depression. Milk thistle can trigger allergic reactions. Milk thistle supplements, for . Medicinal use of this product has not been approved by the FDA. Although rare, milk thistle may trigger a number of common and mild side effects. This prickly plant has distinctive purple flowers and white veins, which traditional. Milk thistle. Herbal Remedies for OCD and Anxiety Disorders - Verywell Mind Have direct benefits against prostate, breast, and certain cervical cancer cells. 2020;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0206/jbcpp-2019-0206.xml. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. See additional information. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: an allergy to plants such as ragweed, chrysanthemums, marigolds, or daisies. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. Milk thistle is native to Europe and was introduced into North America by early colonists. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. 2014;97 Suppl 11:S31-S40. 2014;2014:941085. doi:10.1155/2014/941085. Benefits. Exercise caution and start slow. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. The Gale Encyclopedia of Alternative Medicine, second edition, 2004. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Adv Ther. Amyloid plaques are sticky clusters of amyloid proteins that can build up between nerve cells as you age. Studies have shown improvements in liver function in people with liver diseases who have taken a milk thistle supplement, suggesting it could help reduce liver inflammation and liver damage (9). 2023 Healthline Media LLC. This is especially important if you are taking any other medications for menopause or any blood thinners, such as statins. Milk Thistle. Copyright 1996-2023 Cerner Multum, Inc. Recent research has explored the use of milk thistle. However, there is no solid evidence that supports these claims. Milk thistle is primarily taken in supplements sold as tablets, capsules, or extract primarily to help with liver function. Find out more on the side effects of statins. National Center for Complementary and Integrative Health. Silymarin: not just another antioxidant. Natural Medicines Comprehensive Database: "Milk Thistle Monograph. People mainly use the supplement to treat liver conditions. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. doi:10.1097/CAD.0000000000000211, Fallah M, Davoodvandi A, Nikmanzar S, et al. The mention of any product, service, or therapy is not an endorsement by NCCIH. 2. Call your doctor for medical advice about side effects. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). More research is needed to confirm these results and the safety of milk thistle for breastfeeding mothers (38, 39, 40). Milk thistle may interact with certain medications and supplements. However, human studies are limited and havent yet shown any beneficial effects. Receive the latest, most useful health and wellness articles, tips, special discounts on nutritional supplements and so much more. Uses of Lavender: Everything You Need to Know, 11 Popular Natural Remedies for the Common Cold, Natural Remedies for Alcohol Use Disorder, The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. There's limited evidence, though, for the role of milk thistle in bone health. Psoriasis (Auckl). When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. A double-blind controlled study. . Mayo Clinic does not endorse companies or products. Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. information is beneficial, we may combine your email and website usage information with Our website services, content, and products are for informational purposes only. Closer to a Cancer Cure? Milk thistle. However, the results from studies have been mixed, and not all have found milk thistle extract to have a beneficial effect on liver disease. It can be consumed in supplement form or as a tea. Side effects. Research Breakdown on Milk Thistle - Examine You may opt-out of email communications at any time by clicking on However, few of these claims are supported by solid evidence. Theres some evidence that milk thistle can treat cirrhosis and chronic hepatitis, which can be caused by alcohol abuse, autoimmune disease, or viruses. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. Do not use this product without medical advice if you are pregnant. 3 Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Milk thistle products appear to help the skin heal from damage caused by UVB radiation from the sun and may offer benefits in preventing non-melanoma skin cancers. J Med Assoc Thai. Did you know that milk thistle has recently been touted as a natural remedy to help manage the debilitating symptoms of OCD? Call your doctor if the condition you are treating with milk thistle does not improve, or if it gets worse while using this product. Milk Thistle (Silybum marianum) for Anxiety? If you have breast cancer, uterine cancer, ovarian cancer, endometriosis or uterine fibroids, consider avoiding milk thistle. Pizzorono JE, et al., eds. Facts & Comparisons eAnswers. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Its been suggested that the antioxidant effects of silymarin may have some anticancer effects, which could be helpful for people receiving cancer treatment (9). Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. It is not certain whether milk thistle is effective in treating any medical condition. Clin Exp Pharmacol Physiol. Zhang Z, Wu H, Qi S, Tang Y, Qin C, Liu R, Zhang J, Cao Y, Gao X. Int J Environ Res Public Health. If you are a Mayo Clinic patient, this could Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. It may also make chemotherapy work more effectively against certain cancers and, in some circumstances, even destroy cancer cells (9, 29, 30, 31). Phytother Res. Advanced milk thistle extract contains phytonutrients that fight oxidative stress and support liver health. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. eCollection 2023. And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. Reflux Risk and Relief View More . The terms "milk thistle" and "silymarin" are often used interchangeably. Mastron JK, Siveen KS, Sethi G, Bishayee A.Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. Pain in . One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. Liu HY, Wei HJ, Wu L, Liu SM, Tang YY, Zou W, Wang CY, Zhang P, Tang XQ. An allergic reaction is more common in people who are allergic to other plants in the Asteraceae family, such as ragweed, daisies, marigolds and chrysanthemums. But even if youve figured out how to manage the symptoms and compulsions, the side effects of many FDA-approved OCD medications can introduce a wide swath of issues and side effects. In fact, it has traditionally been used to treat liver and gallbladder disorders, promote breast milk production, prevent and treat cancer and even protect the liver from snake bites, alcohol and other environmental poisons. 2017 Apr;42(4):1073-1083. doi: 10.1007/s11064-016-2141-4. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Someone please correct me if I'm wrong. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. In trying to determine the proper milk thistle OCD dosage, herbalists and experts tend to recommend 200-400mg divided across two or three doses per day (5). Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Now, one substance that we know can inhibit 5-alpha reductase, although it does it pretty weakly, is saw palmetto [200-500mg/Day, 2-3 . Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Scan J Gastroenterol. Risks. 7 likes, 2 comments - lyndsey | nutrition + fertility + herbalism + birth (@rooted_in_ritual) on Instagram: " Ways to Prepare for Ovulation Ovulation is the . Skip the missed dose if it is almost time for your next scheduled dose. People with diabetes often have high cholesterol. Therefore, it may be best to avoid milk thistle during these life stages. Learn more about natural remedies for type 2 diabetes. This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. The information and products shown on this website should not be interpreted as a substitute for physician evaluation or treatment. Milk thistlesupplementscontaining silymarin are commonly sold as teas or in capsule form, but are also available as tablets, soft gels, and liquid extracts. MILK THISTLE Reviews and User Ratings: Effectiveness, Ease of - WebMD 2023 May;475(5):621-635. doi: 10.1007/s00424-023-02795-y. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. metabolic syndrome, depression, cardiovascular diseases and thalassemia, in addition to its photoprotective activity in in vitro tests and preclinical studies. https://naturalmedicines.therapeuticresearch.com. 2021;142:112024. doi:10.1016/j.biopha.2021, Walsh JA, Jones H, Mallbris L, et al. 2005 - 2023 WebMD LLC, an Internet Brands company. The benefits of milk thistle can be attributed to its anti-inflammatory and antioxidant effects. The benefits of milk thistle are believed to come from silymarin, an anti-inflammatory compound present throughout the entire plant, but highly concentrated in milk thistle seeds (4). If you take any medicines regularly, talk to your doctor before you start using milk thistle. CNS Neurosci Ther. The flavonoid complex silymarin in preclinical studies has been found to increase serotonin and dopamine levels in the cortex. Milk thistle may not be safe for everyone. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Do not use this product without medical advice if you are breast-feeding a baby. Other studies looking at milk thistle for cirrhosis have found conflicting results. Follow all directions on the product label and package. [Database subscription]. However, the studies in humans are very limited and have yet to show a meaningful clinical effect in people (32, 33, 34, 35, 36). People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. National Library of Medicine One study questioned the benefits of milk thistle for liver diseases. 5 It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. Milk Thistle is used to treat alcoholic liver disease, gallbladder problems, hepatic cirrhosis, hepatitis (chronic), hepatotoxicity (chemical/drug-induced), jaundice, pleurisy, prostate cancer, and spleen diseases, and used as an appetite stimulant.. Milk Thistle Tea: Benefits, Side Effects, and Dosage - Healthline But the herb is also believed to be beneficial for other health issues. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: How To Make Sense of a Scientific Journal Article, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. a history of endometriosis or uterine fibroids. However, one area of milk thistle research focuses on how it affects bone marrow, which contributes to overall bone health but also has implications in treating diseases like multiple myeloma, a type of blood cancer. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Milk thistle has been used as a traditional remedy for neurological conditions like Alzheimers and Parkinsons disease for over two thousand years (13). Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Fried, M.; Navarro, V.; Afdhal, N. et al. 2016;2016:5147468. doi:10.1155/2016/5147468, Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Milk thistle has a distinctive purple flower and spiky leaves, grows to about 200 cm in height, and is found throughout the world. An official website of the United States government. Milk Thistle in Trichotillomania in Children and Adults Historically, people have used milk thistle for liver disorders and gallbladder problems. Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. Quality and active ingredients in supplements may vary widely from maker to maker. National Center for Complementary and Integrative Health. Era of Hope Meeting for the Department of Defense Breast Cancer Research Program, Atlanta, June 8-11, 2000. Silibinin-treatment up-regulated the function through BDNF/TrkB pathway and attenuated autophagy in the hippocampus. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. The best doses of milk thistle have not been established for any condition it may be used to treat. Milk thistle has been an important natural remedy for centuries of folk medicine practitioners. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. However, there is a lack of . Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Milk thistle ( Silybum marianum) is an herbal remedy used mainly to protect and detoxify the liver. N-Acetylcysteine Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. National Library of Medicine (US); 2022. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. This content does not have an English version. 2015;26(5):475486. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. This site needs JavaScript to work properly. The silymarin extracted from milk thistle is known to have antioxidant, antiviral and anti-inflammatory properties (2, 3, 4). Before We comply with the HONcode standard for trustworthy health information. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Milk thistle has been shown in experimental test-tube and animal studies to stimulate bone mineralization and potentially be protective against bone loss (22, 23). PMC Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Milk Thistle Benefits: 15 Ways This Super Herb Can Improve - Organixx By using our site, you acknowledge that you have read and understand our. Milk Thistle: Health Benefits, Safety Information, Dosage, and More - WebMD Osteoporosis is a disease caused by progressive bone loss. The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). Available for Android and iOS devices. It is not known whether milk thistle passes into breast milk or if it could harm a nursing baby. Natural Medicines. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Milk thistle extract has a high amount of silymarin (between 6580%) that has been concentrated from the milk thistle plant. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. Unauthorized use of these marks is strictly prohibited. Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. Researchers believe that silymarin reduced the oxidative stress traditionally attributed with diabetes (7). Join 45,000+ subscribers and receive the latest, useful and exclusive health and wellness articles, health tips, special offers and more - delivered direct to your inbox. Milk thistle and its antioxidant properties are promising in managing OCD symptoms but it may also be beneficial to explore other herbs for OCD treatment to bolster and round out a supplement regimen. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Brain Fog (anxiety, depression, ADHD), lots of medications. Moreover, silibinin was able to attenuate the neuronal damage in the hippocampus of A1-42-injected rats. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Silibinin ameliorates anxiety/depression-like behaviors in - PubMed FOIA . the unsubscribe link in the e-mail. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Some people are advised to be cautious when taking milk thistle. How Does Cirrhosis Affect Life Expectancy? Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Its herbal remedy is known as milk thistle extract. Phytomedicine. In 2010, a double-blind, placebo-controlled study compared the effects of milk thistle to the antidepressant Prozac (fluoxetine) in treating OCD (600 milligrams of milk thistle vs 30 milligrams of Prozac daily). In reducing oxidative stress, milk thistle is believed to be neuroprotective by helping prevent decline in brain function. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Milk thistle contains compounds that may support skin, liver, and bone health and enhance weight loss. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. This publication is not copyrighted and is in the public domain. Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. There is not enough scientific data to say whether or not milk thistle can help liver problems. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). Phytomedicine. Accessed Oct. 30, 2020. Researchers also have found that milk thistle improved insulin resistance, a key part of type 2 diabetes. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Summary In animals, milk thistle has been shown to stimulate bone mineralization. Unexpected effects from milk thistle. 1. I think milk thistle is often used in combo with NAC to enhance it's beneficial effects. However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. . include protected health information. Comparing Natural Remedies for OCD to Standard OCD Treatment The benefits of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. JIN_FK8R Please rate my stack I know I'm Fxxked up for now. Consult with a licensed healthcare professional before using any herbal/health supplement. A 2010 review by researchers found that black . Some people have nausea, diarrhea, itching, and bloating. Silymarin is an active component of milk thistle, which is not found in foods. Milk thistle is not recommended for children. We encourage you to discuss any decisions about treatment or care with your health care provider. Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; This is not a complete list of side effects and others may occur. Unable to load your collection due to an error, Unable to load your delegates due to an error. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. de Avelar CR, Pereira EM, de Farias Costa PR, et al. As a result, researchers suggest that milk thistle may be a useful therapy for preventing or delaying bone loss in postmenopausal women (24, 25). Additionally, the antioxidant and anti-inflammatory properties of milk thistle may also be useful for reducing the risk of developing diabetic complications like kidney disease (43). By Brittany Lubeck, RD Ask your doctor for advice. Keep in mind that supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider.
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